MicroRNA Evolution in the Human Genome
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چکیده
Micro ribonucleic acids (miRNAs) are a growing class of small RNA [ 22nucleotide (nt)] that function as negative regulators in the genome by targeting messenger RNA (mRNA) for translational repression, cleavage and destabilization. Hundreds of miRNAs havebeen identified in the humangenome.miRNAs canbe conservedor nonconserved according to their cross-species sequence conservation, and these two classes of miRNAs in the human genome are subject to distinct evolutionary patterns.
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تاریخ انتشار 2008